Myriam Cilla Hernández
Main Fields of Research Education Work Experience Abroad stays Publications Main Research Projetcs
- Bioengineering and biomechanic
- Finite Element Methods and Computational fluid dynamics
- Experimental methodologies to validate computational models
- Advanced numerical methods
- Constitutive models in nonlinear solid Mechanics
- Material behavior and mechanics of the deformable solids
- 2009 - 2013: Doctor of Philosophy in Computational Mechanics.
European doctorate (English-language process). Designated as Excellent by the Spanish Ministry of Education and Science (MEC 2007-08 A 2010-11, B.O.E. nº 140, 12nd June 2003). College of Higher Engineering and Architecture (EINA). University of Saragossa. Saragossa (Spain). Dissertation:“Mechanical effects on the atheroma plaque appearance, growth and vulnerability”. Faculty Advisors: Prof. Dr. Miguel Ángel Martínez Barca (University of Saragossa) & Prof. Dr. Estefanía Peña Baquedano (University of Saragossa)
- 2011 - 2012: MSc in Applied Mechanics.
College of Higher Engineering and Architecture (EINA). University of Saragossa. Saragossa (Spain).
- 2009 - 2010: Diploma of Advanced Studies in Computational Mechanics.
Two years Post-MSc. studies, Spanish Ministry of Education recognition of research ability). Higher Polytechnic Centre (CPS). University of Saragossa. Saragossa (Spain).
- 2003 - 2008: (BSc+MSc) Industrial Engineering.
Minor in machinery and vehicles design. Higher Polytechnic Centre (CPS). University of Saragossa. Saragossa (Spain).
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Oct 2015-Onwards - Assistant Professor
Institution: Centro Universitario de la Defensa. Academia General Militar Zaragoza (Spain)
Brief description: Teaching "Computer-Aided Design & Enginnering Drawing" at the Centro Universitario de la Defensa (CUD) Zaragiza & Research at the Aragon Institute for Engineering Research (I3A). Applied Mechanics and Bioengineering (AMB) group. University of Zaragoza. Zaragoza (Spain)
Apr 2013-Sep 2015 Postdoctoral Research Fellow
Institution: Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration. Charité - Universitätsmedizin Berlin. Traumatology and Orthopedic Surgery. Berlin (Germany)
Brief description: Computational analysis based on Finite Element (FE) methods of bone mechanics and better understanding of the mechanics of Total Hip Artroplasty (THA)
Advisors: Prof. Dr. Georg N. Duda and Prof. Dr. Sara Checa Esteban
Jan 2009-Feb 2013 Research Assistant
Institution: Aragon Institute for Engineering Research (I3A). Applied Mechanics and Bioengineering (AMB) group. University of Zaragoza. Zaragoza (Spain)
Brief description: Role of mechanical factors on atherosclerotic blood vessels within the continuum mechanics framework: Computational analysis based on Finite Element (FE) methods, Fluid Structure Interaction (FSI) analysis and plaque growth models using reaction-diffusion-convection equations. Experimental test in mice. Design and development of stents or biomaterial for cardiovascular therapies.
Advisors: Prof. Dr. Miguel Ángel Martínez Barca and Prof. Dr. Estefanía Peña Baquedano.
Apr 2013-Sep 2015 Postdoctoral Research
Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration. Charité - Universitätsmedizin Berlin. Traumatology and Orthopedic Surgery. Berlin (Germany)
Brief description: Computational analysis based on Finite Element (FE) methods of bone mechanics and better understanding of the mechanics of Total Hip Artroplasty (THA)
Advisors: Prof. Dr. Georg N. Duda and Prof. Dr. Sara Checa Esteban
Mar 2012-Jun 2012 Visiting Research Assistant
School of Medicine of Grenoble. Laboratory of Imaging Techniques and Modeling (TIMC). Grenoble (France)
Brief description: Experiments of blood vessels aperture angle. Lab training
Advisor: Prof. Dr. Jacques Ohayon
Jan 2011-May 2011 Visiting Research Assistant
Trinity College Dublin. Trinity Centre for Bioengineering (TCBE). Dublin (Ireland)
Brief description: Computational analysis based on Finite Element (FE) methods of the role of positive and negative atheroma plaque morphology on the plaque rupture
Advisor: Prof. Dr. Daniel J. Kelly
Sep 2007-Jun 2008 Erasmus stay
Faculty of Power and Aeronautical Engineering. Warsaw University of Technology (Poland).
RESEARHER ID profile here & Google Scholar profile here
Peer-reviewed Publications - Original articles
1.- Cilla M., Pérez-Rey I., Martínez M.A, Peña E. and Martínez J. On the Use of Machine Learning Techniques for the Mechanical Characterization of Soft Biological Tissues. International Journal for Numerical Methods in Biomedical Engineering. 34 (10): e3121, 2018.
2. Albiol L., Cilla M., Pflanz D., Kramer I., Kneissel M., Duda G.N., Willie B.M., Checa S. Sost Deficiency leads to reduced mechanical strains ath the tibia midshafts in strain-matched in-vivo loading experiments in mice. Journal of the Royal Society Interface. 15(141): 20180012, 2018.
3. Cilla M., Borgian E., Martínez J., Duda G.N., Checa S. Machine learning techniques for the optimization of joint replacements: Application to a short-stem hip implant. PLoS ONE. 12(9):e0183755, 2017.
4. Cilla M., Checa S., Preininger B., Winkler T., Perka C., Duda G.N., Pumberger M. Femoral Head Necrosis: A Finite Element Analysis of Common and Novel Surgical Techniques. Clinical Biomechanics. 48:49-56, 2017.
5. Cilla M., Checa S., Duda G.N. Strain shielding inspired re-design of proximal femral stems for total hip arthroplasty. Journal of orthopaedic research. In press, 2017.
6. Waffenschmidt T., Cilla M., Saéz P., Pérez M., Martínez M.A., Menzel A., Peña E. Towards the modelling of ageing and atherosclerosis effects in Math Eq mice aortic tissue. Journal of Biomechanics. 49(12): 2390–2397, 2016.
7. Cilla M., Pérez M., Peña E. and Martínez M.A. Effect of diet and age on arterial stiffening due to atherosclerosis in ApoE-/- mice. Annals of Biomedical Engineering, 44(7): 2202-2217, 2016.
8. Cilla M.,Borrás I., Peña E., Martínez M.A. and Malvè M. A parametric model for analysing atherosclerotic arteries: on the FSI coupling. International Journal of Heat and mass Transfer, 67: 29-38, 2015.
9. Cilla M.,Peña E. and Martínez M.A. Effect of transmural transport propertieson atheroma plaque formation and development. Annals of Biomedical Engineering, 43(7):1516-30, 2015.
10. Araña M., Gavira J.J., Peña E., Gonzáles A., Abizanda G., Cilla M., Albiasu E., Aguado N., Casado M., González S., Soriano M., Moreno C., Merino J., García-Verdugo J.M., Diez J. Doblaré M., Pelacho B. and Prósper F. Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction. Biomaterials, 35(1): 143-15, 2014.
11. Cilla M.,Peña E. and Martínez M.A. Mathematical modeling of atheroma plaque formation and development in coronary arteries. Journal of the Royal Society Interface, 11(90): 20130866, 2013.
12. Cilla M.,Monterde D., Peña E. and Martínez M.A. Does microcalcification increase the risk of rupture? Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine, 227:588-599, 2013.
13. Araña M., Peña E., Abizanda G., Cilla M., Ochoa I., Gavira J.J., Doblaré M., Pelacho B. and Prósper F. Preparation and characterization of collagen-based ADSC-carrier sheets for cardiovascular application. Acta Biomaterialia, 9: 6075-6083, 2013.
14. Cilla M.,Peña E., Martínez M.A. and Kelly D.J. Comparison of the vulnerability risk for positive versus negative atheroma plaque growth. Journal of Biomechanics, 46: 1248-1254, 2013.
15. Cilla M.,Martínez J., Peña E. and Martínez M.A. Machine Learning Techniques as a Helpful Tool towards Determination of Plaque Vulnerability. IEEE Transactions on Biomedical Enginering, 9(4):1155-61, 2012.
16. Cilla M.,Peña E. and Martínez M.A. 3D computational parametric analysis of eccentric atheroma plaque influence of axial and circumferential residual stresses. Biomechanical and Modeling Mechanobiology, 11(7):1001-13, 2012.
Peer-reviewed Publications - Other contributions
1. Cilla M.,Peña E. and Martínez M.A.A 3D parametric study of eccentric atheroma plaque: influence of Geometrical factors and residual stress. Journal of Biomechanics, 45:S137, 2012.
2. Cilla M.,Pérez M.M., Peña E. and Martíinez M.A. Mechanical properties of atheroma plaque along the length of the aorta in ApoE (-/-) mice model. Journal of Biomechanics, 45:S18, 2012.
Peer-reviewed conference contributions
1. Heyland M., Duda G.N., Urda A.L.,Cilla M. and Märdian S. Fracture risk for ipsilateral stemmed implants. 23rd Congress of the European Society of Biomechanics (ESB), Seville (Spain). Podium presentation
2. Cilla M., Pérez M.M., Peña E. and Martínez M.A. Hemodynamic analysis of mice aortas. Correlation with atheroma plaque appearance. 23rd Congress of the European Society of Biomechanics (ESB), Seville (Spain). Podium presentation.
3. Heyland M., Duda G.N., Urda A.L.,Cilla M. and Märdian S. Analytical model prediction of interprostic fracture risk. Deutscher Kongress für Orthopädie und Unfallchirurgie 2017 (DKOU2017). Berlin (Germany). Podium presentation.
4. Albiol-Sánchez L., Pflanz D., Cilla M., Kramer I., Kneissel M., Duda G.N., Zaslansky P., Willie B.M. and Checa S. Sost deficiency leads to a reduction in the mechanical strains induced within the mouse tibia. Orthopedic Research Society (ORS) 2017 Annual Meeting. San Diego, CA (EEUU). Poster presentation.
5. Cilla M., Pérez M.M., Peña E and Martínez M.A. Effects of the atherosclerosis progression: Variation of mechanical properties along the length of mouse aorta. IV Congreso Nacional I+D en Defensa y Seguridad (DESEID2016). San Javier (Spain). Podium presentation.
6. Cilla M., Peña E. and Martínez M.A. Mathematical model of atheroma plaque formation and development hypertension effect on the plaque growth. 12th World Congress on Computational Mechanics (WCCM XXII) & 6th Asia-Pacific Congress on Computational Mechanics (APCOM VI). Seoul (Korea). Flash presentation.
7. Märdian S., Duda G.N., Schwabe P., Moewis P.R., Cilla M., Heyland M. Fracture risk as a function of inter-prosthetic distance. Risk analysis in Finite Element Analysis. 22st Congress of the European Society of Biomechanics (ESB), Lyon (France). Podium presentation.
8. Cilla M., Peña E. and Martínez M.A. Mathematical model of atheroma plaque formation and development hypertension effect on the plaque growth. 22st Congress of the European Society of Biomechanics (ESB), Lyon (France). Flash presentation.
9. Borgiani E., Checa S., Martínez J., Duda G.N. and Cilla M. Geometrical optimization of a short-stem hip implant for the reduction of proximal stress shielding. 21st Congress of the European Society of Biomechanics (ESB), Prague (Czech Republic), 2015. Podium presentation
10. Peña E., Cilla M. and Martínez M.A. Mechanobiology model of the atheroma plaque formation and development to study the effect of transmural transport properties. 21st Congress of the European Society of Biomechanics (ESB), Prague (Czech Republic), 2015. Poster presentation
11. Cilla M.,Duda G.N. and Checa S. Bone adaptation in young and elderly patients after short-stem hip implantation. 7th World Congress of Biomechanics (WCB). Boston (EEUU), 2014. Poster presentation
12. M. M Pérez. M. Cilla, E. Peña and M.A. Martínez. The role of age and diet in stiffening of ApoE mouse aorta.7th World Congress of Biomechanics (WCB). Boston (EEUU), 2014. Poster presentation
13. Cilla M., Checa S. and Duda G.N.Periprosthetic mechanics after Total Hip Arthroplasty (THA). Alterations in bone mechanical strains after long and short stem implantation: A Finite Element (FE) study. Deutscher Kongress für Orthopädie und Unfallchirurgie 2013 (DKOU2013). Berlin (Germany). Podium presentation.
14. Cilla M.,Kelly D.J., Monterde D., Peña E. and Martínez M.A. Advanced features to take into account to assess atheroma plaque vulnerability. 19th Congress of the European Society of Biomechanics (ESB), Patras (Greece), 2013. Poster presentation
15. Peña E., Cilla M. and. Martínez M.A. Mathematical modeling of atheroma plaque formation and development. 19th Congress of the European Society of Biomechanics (ESB), Patras (Greece), 2013. Podium presentation
16. Malvè M., Cilla M., Borrás I., Peña E. and Martínez M.A. Parametric study of an atherosclerotic artery using fluid-structure interaction approach. 19th Congress of the European Society of Biomechanics (ESB), Patras (Greece), 2013. Podium presentation
17. Cilla M.,Peña E. and Martínez M.A. On the time dependent mathematical model of atheroma plaque formation. II Jornada de Jóvenes Investigadores I3A, Zaragoza, (Spain), 2013. Podium presentation
18. Cilla, M.,Pérez M.M., Peña E. and Martínez M.A. Propiedades mecánicas de la aorta durante el proceso de formación de placa aterosclerótica en ratones ApoE(-/-). II Reunión del Capítulo Nacional de la Sociedad Europea de Biomecánica (ESB), Sevilla, (Spain), 2012. Podium presentation
19. Cilla M.,Martínez J., Peña E. and Martínez M.A. Atheroma plaque vulnerability prediction using Machine Learning Techniques. XXIII International Congress of Theoretical and Applied Mechanics (ICTAM), Pekin, (China), 2012. Podium and poster presentation
20. Martínez M.A., Cilla M. and Peña E. A 3D parametric study of eccentric atheroma plaque: influence of Geometrical factors and residual stress. 18th Congress of the European Society of Biomechanics (ESB), Lisbon (Portugal), 2012. Podium presentation
21. Cilla M.,Pérez M.M., Peña E. and Martíinez M.A. Mechanical properties of atheroma plaque along the length of the aorta in ApoE (-/-) mice model. 18th Congress of the European Society of Biomechanics (ESB), Lisbon (Portugal), 2012. Podium presentation
22. Cilla M.,Monterde D., Peña E. and Martínez M.A. The microcalcification influence on the ateroma plaque vulnerability. I Jornada de Jóvenes Investigadores I3A, Zaragoza, (Spain), 2012. Podium presentation
23. Cilla M.,Martínez J., Peña E. and Martínez M.A. Red Neuronal Artificial para la toma de decisiones en la vulnerabilidad de placa de ateroma. I Reunión del Capítulo Nacional de la Sociedad Europea de Biomecánica (ESB), Zaragoza, (Spain), 2011. Podium presentation
24. Cilla M.,Peña E. and Martínez M.A. Red Neuronal Artificial para la toma de decisiones en la vulnerabilidad de la placa de ateroma. Congress on Numerical Methods in Engineering (CNME), Coimbra, (Portugal), 2011. Podium presentation
25. Cilla M.,Peña E., Martínez M.A. and Doblaré, M. 3D parametric study of the biomechanical factors in evaluating the risk of plaque rupture. 17th Congress of the European Society of Biomechanics (ESB), Edinburgh, Scotland (United Kingdom), 2010. Podium presentation
26. Cilla M.,Peña E., Martínez M.A. and Doblaré, M. Computational modelling of atheroma plaque: biomechanical factors in the risk of plaque rupture. IV European Congress on Computational Mechanics (ECCM IV): Solids, Structures and Coupled Problems in Engineering, Paris (France), 2010. Podium presentation
27. Cilla M.,Peña E., Martínez M.A. and Doblaré, M. Estudio paramétrico tridimensional de factores geométricos en la vulnerabilidad de la placa de atheroma. XXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), Cádiz (Spain), 2009. Podium presentation.
Public funding
1. Patient-Specific Modelling of the Aortic valve replacement: Advance towards a Decision Support System. Financial Support: Proyecto intramural CIBER-BBN (Biomedical Research Networking center in Bioengineering, Biomaterials and Nanomedicine). Principal investigator: Mauro Malvè. Participant institutions: University of Saragossa (Spain), University of Valencia (Spain) and Public University of Navarre (Spain).2016-2017.
2. Prediction of drug diffusion on complex biomimetic environment. Financial Support: Proyecto intramural CIBER-BBN (Biomedical Research Networking center in Bioengineering, Biomaterials and Nanomedicine). Principal investigator: Sara Oliván García. 2016-2017.
3. In silico-in vitro analysis of atheromaplaque formation and development (DPI2016-76630-C2-1-R). Financial Support: Spanish Ministry of Economy and Competitiveness. Principal investigator: Estefanía Peña Baquedano & Miguel Ángel Martínez Barca. 2017-2020.
4. Characterization of the microstructure of soft biological tissue samples by computerized microtomography (micro-CT) (CUD2015-03). Financial support: Centro Universitario de la Defensa. Spanish Ministry of Defense. Principal investigator: Myriam Cilla Hernández. 2016
5. Numerical analysis and optimization of drug-eluting intravascular devices. Application to stents and balloons design for treating atherosclerosis. DPI2013-44391. Financial Support: Spanish Ministry of Economy and Competitiveness. Principal investigator: Miguel Ángel Martínez Barca & Estefanía Peña Baquedano. 2014-2016
6. Modelling and simulation of the aging of arteries due to the atherosclerosis. PRI-AIBDE-2011-1216. Financial Support: Spanish Ministry of Science and Innovation. Principal investigator: Estefanía Peña Baquedano. 2012-2014
7. Design of a computational tool to study fluid structure interaction problems in the cardiovascular field. CYCIT DPI2010-20746-C03-01. Financial Support: Spanish Ministry of Science and Innovation. Principal investigator: Miguel Ángel Martínez Barca. 2011-2013
8. Study of the anatomical, histological and mechanical characteristics of murine aorta during the atherosclerosis development. UZ2008-BIO-21. Financial Support: University of Zaragoza (Spain). Principal investigator: Marta Mª Pérez Rontomé. 2009
9. Design and development of a new prototype of an intravascular device (stent) with variable radial force for stenotic lesions of carotid arteries. CYCIT DPI2007-63254. Financial Support: Spanish Ministry of Science and Innovation. Principal investigator: Miguel Ángel Martínez Barca. 2007-2010
10. Characterization of cardiovascular disease by imaging techniques (Cardiovim). PSE-010000-2008-1. Singular Strategic Project Program. Financial Support: Spanish Minisry of Science and Technology. Principal investigator: Manuel Doblaré Castellano. 2008-2010
11. Biomaterials for cardiovascular therapies (Clevermat). PSS-010000-2008-1. Singular Strategic Project Program. Financial Support: Spanish Minisry of Science and Technology. Principal investigator: Manuel Doblaré Castellano. 2008-2010
Technology Transfer Projects
1. Advances in the design of intelligent containers for induction cookers. Industrial partner: BSH Electrodomésticos España S.A. 2016-2017.
2. Periprosthetic mechanics after implantation of a novel anatomical, uncemented hip prosthesis stem in Total Hip Arthroplasty (THA). Industrial partner: Waldemar Link GmbH & Co. KG. 2014-2015
3. Periprosthetic mechanics after Total Hip Arthroplasty (THA). Industrial Partner: Smith & Nephew Orthopaedics AG. 2013-2015.
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